JCMT:颊粘膜鳞状细胞癌的骨转移发生率
2015/9/29 创新医学网

    

     由于吸烟及不良的口腔卫生等因素,头颈部癌成为困扰印度人健康的主要难题。其中颊粘膜鳞状细胞癌非常常见,在接诊的所有恶性肿瘤患者中,有约2.5%为头颈癌,多数患者一经发现就处于晚期(III/IV期),因此,其生存率非常低。

     颊粘膜鳞状细胞癌骨转移在世界范围内极其罕见,但在印度较为突出。对过去5年内被诊断为颊粘膜癌患者发生骨转移的情况进行统计分析。

     结果显示在确诊后一年内发生骨转移的患者大多比较年轻,有吸烟史,转移部位主要发生于扁平骨和脊椎骨,患者在确认骨转移后,尽管接受了局部放疗和化疗,但生存时间依旧很短。目前,颊粘膜癌频繁发生骨转移的原因尚不清楚,但原发性肿瘤根除前恶性细胞的亚临床接种是其骨转移的原因。所以诊断为晚期颊粘膜癌时,应在局部病灶处进行骨扫描以确定最后的治疗方案。

     Incidence of bone metastasis in squamous cell carcinoma of the buccal mucosa

     Aim: This retrospective study was performed to show the incidence of bone metastasis from carcinoma of the buccal mucosa. Head and neck cancer is a leading health problem in India due to an increased incidence of tobacco use and poor oral hygiene. Squamous cell carcinoma of the buccal mucosa is common and roughly 2.5% of all malignancies that present to our center. Moreover, most patients present at late stages (III/IV) and consequently, survival rates are low. Bone metastasis in advanced cases of such carcinomas is rarely reported worldwide but is more prominent in parts of India. Methods: Here, we present a series of patients diagnosed with buccal mucosa carcinomas within the past 5 years that also demonstrated bone metastases. Results: These patients were young, with a history of tobacco chewing with locally advanced disease and bone metastases that developed within one year of diagnosis. Flat bones and vertebrae were mainly involved and the survival was short after diagnosis of metastasis despite treatment with local radiotherapy and chemotherapy. Although the mechanism of such frequent metastases remains unknown, subclinical seeding of malignant cells before the eradication of the primary tumor may be the cause of advanced bone metastasis. Conclusion: A pretreatment bone scan should be performed in locoregionally advanced buccal mucosa carcinomas at the time of diagnosis to define the treatment plan.

     Keywords: Bone metastases, head and neck cancer, squamous cell carcinoma

     How to cite: Bhandari V. Incidence of bone metastasis in squamous cell carcinoma of the buccal mucosa. J Cancer Metastasis Treat 2015;1:27-30.

     原文链接:

     http://jcmtjournal.com/article.asp?issn=2394-4722;year=2015;volume=1;issue=1;spage=27;epage=30;aulast=Bhandari

    

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