博士后招聘2则，来自麻省理工学院和约翰霍普金斯大学医学院

博士后招聘2则，来自麻省理工学院和约翰霍普金斯大学医学院
2019/11/13 7:28:00 学术经纬





     ▎学术经纬/报道

     Postdoctoral Associate - Therapeutic Nucleic Acid Delivery - The Massachusetts Institute of Technology

     Location：Boston, MA, US

     REQUIREDPh.D. in molecular biology, biochemistry, or related field; expertise in molecular cloning, mammalian cell culture and transfection, qRT-PCR, and RNA-seq; strong interpersonal, communication, and scientific skills; and a strong publication record. Experience with in vivo delivery of therapeutic nucleic acids using LNPs, AAV, or other vector, plus downstream quantitative analysis of therapeutic efficacy using genomic, transcriptomic, and proteomic tools is highly desirable. Seek a highly motivated and detail-oriented postdoc who is biomedically and translationally focused and has a strong desire to translate novel gene therapeutic formulations to the clinic. Job #18139

     In addition to applying online with a CV and cover letter via the MIT website, please submit a letter of intent on how this position relates to your past experience, a CV describing relevant projects and skills, a list of your relevant publications, and contacts for three academic references via email (with "postdoctoral associate" in the subject line) to lcbb.search@gmail.com.

     Application deadline: February 1, 2020, or until filled.

     Biological Engineering, to lead cutting-edge research into the formulation and in vivo application of therapeutic nucleic acids for cancer and gene therapies in the Laboratory of Professor Mark Bathe (http://bionanolab.org). A major bottleneck to all of cancer and gene therapeutics is the targeted in vivo delivery of therapeutic nucleic acids including siRNAs, mRNA, ASOs, and CRISPR ribonucleoproteins. The Bathe lab is developing structured nucleic acid nanoparticles for this purpose, functionalized with targeting ligands ranging from peptides to lipids and sugars. Responsibilities will include working as part of collaborative interdisciplinary teams at MIT, the Koch Institute for Integrative Cancer Research, the Broad Institute of MIT & Harvard, and Harvard Medical School to design, synthesize, and evaluate novel gene therapeutics using a range of in vivo and in vitro models.

     Postdoctoral Fellow - Institute for Cell Engineering - The Johns Hopkins University

     Location: Baltimore, MD, US

     The Department of Surgery at the Johns Hopkins University in Baltimore, Maryland, is seeking a highly motivated postdoctoral scientist to join our NIH-funded pediatric surgery research group directed by Dr. Shaun Kunisaki, an affiliate member of the Institute for Cell Engineering.

     https://www.hopkinsmedicine.org/institute_cell_engineering/experts/affiliates.html

     This basic and translational research laboratory focuses on the regeneration of fetal organs (lung, esophagus, spinal cord) that have been injured prior to birth. We collaborate with other laboratories at Hopkins and elsewhere with expertise in cell biology and biomedical engineering.

     REQUIRED

     The applicant must have a PhD (or equivalent degree) and an outstanding record of research productivity. The ideal candidate has an interest in lung and/or neural development. He/she will independently perform laboratory experiments based on established procedures and protocols, including cell reprogramming towards pluripotency, in vitro modeling, animal surgeries, immunohistochemistry, and confocal microscopy. Candidates with strong cell culture experience are preferred.

     Duties And ResponsibilitiesPlans approach to experiments based on knowledge of scientific theory regarding fetal organ development and injury

     Independently performs day-to-day lab experiments by following established procedures and protocols and utilizing appropriate technique

     Maintains accurate data records and laboratory notebook.

     Maintains and makes necessary adjustments to equipment, e.g., calibrating, alignment

     May be responsible for routine operational activities such as ordering supplies and materials, reviewing inventory, maintaining up to date records of tests, maintenance of human and animal welfare protocols

     Prepares solutions, reagents, and stains following standard laboratory formulas and procedures

     Maintains and improves training procedures and is responsible for training entry-level employees on relevant techniques

     Additional responsibilities may include instructing/assisting students and postdocs contributing to general maintenance of the laboratory, equipment, and supplies

     Strong oral presentation and writing skills, resulting in manuscript development, drafting, and submission as first author or co-author

     Travel may be required

     Schedule flexibility to include occasional weekend and holidays commitment may be required

     Other duties may also be assigned

     Education & Experience

     PhD or equivalent degree in biology, chemistry, or related field.

     Special Knowledge, Skills, And AbilitiesRelevant techniques include histology, immunohistochemistry, microscopy, PCR, microarray, next generation sequencing, rodent surgery,Ability to reprogram somatic cells towards pluripotency and to maintain induced pluripotent stem cell culture

     Willingness to learn new techniques

     Excellent organizational skills and demonstrated ability to accurately complete detailed work

     Comfortable with handling small animals

     Excellent interpersonal and communication skills with a multi-disciplinary and collaborative environment

     Ability to work on multiple assignments, set priorities, take initiative in defining and executing tasks, exhibit flexibility to respond to casual requests, exercise good judgement

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