新发现：胃部感染和帕金森症有密切关联
2016/6/14 0:32:27Medical Xpress 世界医疗科技资讯

    

     研究人员在报告称，常见细菌感染人类的胃与帕金森病的症状恶化有重大关联。文章发表在近日Medical Xpress 上。

     帕金森病是世界上第二种最常见的神经退行性疾病，会引起肢体震颤，减少运动的协调性。该病的原因仍然未知，医生目前只能治疗疾病的症状。

     马来西亚大学的研究人员分析了一小群帕金森症患者，他们有的携带，有的未携带感染幽门螺杆菌的胃粘膜。他们的研究结果显示，约占总数三分之一的感染测试与帕金森病相关。

     在机动性能测试中受病菌感染的患者被治疗后会减少帕金森病症状。

     超过一半的世界人口携带幽门螺杆菌，感染率最高的国家在亚洲。它会影响肠道粘膜发展，引起慢性感染，经常在儿童时期感染细菌。这种细菌可以导致一系列消化道疾病，该细菌可以无限繁殖除非经过治疗，虽然有些患者还没有显示出任何症状。

     研究者提出了两个主要的理论来解释他们的结果。首先，感染可以减少左旋多巴的吸收，这种药物可以减少帕金森病的症状。经过进一步推测，慢性幽门螺杆菌感染可能加剧甚至引起帕金森病。然而，他们也推测，帕金森病也可能使患者更容易感染幽门螺杆菌。

     研究人员说他们对103名受试者进行研究，目的主要是确认幽门螺杆菌感染和帕金森病之间的联系。

     但是他们说他们发现幽门螺杆菌感染和帕金森病症状的恶化之间的联系非常紧密，由此可以设计临床试验来证实它，更深入的探讨其原因。

     原文阅读：

     Link found between stomach infection and Parkinsons symptoms

     Researchers report that a common bacterium infecting the human stomach has significant links with worsened symptoms of Parkinson's disease. Parkinson's disease is the world's second most common neurodegenerative disorder, causing tremors and decreasing motor coordination. Causes are elusive and doctors currently can only treat its symptoms. Researchers at the University of Malaya analysed a small group of Parkinson's disease patients with and without a common infection of the stomach lining caused by the bacterium Helicobacter pylori. Their results showed that those with the infection – about a third of the total – tested worse in motor problems related to Parkinson's disease. Subjects whose infection could be treated and eradicated showed fewer Parkinson's disease symptoms in motor performance tests, while those who stayed infected had further declines in their test results. More than half of the world's population carries H. pylori, with the highest infection rates in Asian countries. It affects mucous membranes in the gut and causes chronic infections, often contracted during childhood. The bacterium can cause a range of digestive tract disorders and can linger indefinitely unless treated, although some subjects show few symptoms. The researchers propose two main theories to explain their results. The first is that the infection may reduce the uptake of levodopa, a drug that reduces symptoms of Parkinson's disease. More speculatively, chronic H. pylori infections might aggravate or even trigger Parkinson's disease. However, they also speculate that it's possible that Parkinson's disease may make subjects more prone to contracting the infection. The researchers say their limited study of 103 subjects aimed mainly to confirm the link between Helicobacter pylori infection and Parkinson's disease suggested by previous, less rigorous research. In addition to its size, the study was limited by the fact that it took place in a single Malaysian clinic and that it was cross-sectional; so it was essentially a data snapshot taken at a certain place and time. But they say the link they found between the infection and worsened symptoms of Parkinson's disease is strong enough to justify further, larger, well-designed clinical trials to confirm it and investigate its causes in more depth.

     http://medicalxpress.com/news/2016-06-link-stomach-infection-parkinsons-symptoms.html

    

     长按二维码扫描关注

    http://weixin.100md.com
返回 世界医疗科技资讯 返回首页 返回百拇医药