【文献解读】组织再生在痤疮瘢痕治疗的应用
2017/8/2 创新医学网

     文章来源：欧尔意 OAE 微信号

     作者 :sofina

    

     原文出处

     Barone M, Tenna S, Cogliandro A, Panasiti V, Nobile C, Persichetti P. Application of regenerative medicine in treatment of acne scars. Plast Aesthet Res 2016; 3:235-9.

     DOI:10.20517/2347-9264.2016.42.

     摘要

     目的：本文旨在评价纳米脂肪和富血小板血浆(PRP)皮下注射以及CO₂点阵激光用于萎缩性痤疮瘢痕的效果，并采用调查表分析患者的满意度。方法：2014年3月至2015年6月，30个颊部痤疮瘢痕的患者入组此前瞻性研究。患者于术前术后接受常规大体检查，照相，并采用22MHz的超声探头扫描测定皮下组织的厚度。所有患者均接受纳米脂肪和PRP皮下浸润注射治疗。 PRP采用Regenlab THT管方法制备。随后患者被随机分为两组，A组继续接受15W的 CO₂点阵激光治疗，B组无激光治疗。采用标准的生活质量问卷(QoL-Q)分析患者的外观改善及满意度。结果：术前皮下组织的厚度A组为0.532mm，B组为0.737mm，术后A组为1.201mm，B组为1.367mm.皮下组织的厚度增厚A组为0.668mm，B组为0.630mm，经非配对t检验，术后皮下组织厚度增加两组无明显差异(P = 0.7289)。所有患者均获得了临床改善。结论：纳米脂肪和PRP浸润注射结合CO₂点阵激光可以有效改善萎缩性痤疮瘢痕，然而，单纯使用纳米脂肪及PRP浸润注射亦可明显增加皮肤及皮下脂肪的厚度。QoL-Q证实了面部痤疮瘢痕对患者社交及生活质量的影响。

     关键词：痤疮；瘢痕；再生；激光；纳米脂肪。

     Aim:The aim of this study is to evaluate the efficacy of the protocol of nanofat and platelet-rich plasma (PRP) infiltration and fractional CO₂ laser resurfacing for face atrophic scars by acne and to analyse patient’s satisfaction with the original questionnaire. Methods:From March 2014 to June 2015, 30 patients with acne scarsonthe cheeks were selected for this pilot study. Patients were evaluated pre- and postoperatively by a physical examination, photographs and ultrasound scan with a 22 MHz probe to measure subcutaneous tissue thickness. All patients were treated by infiltration of nanofat and PRP. The production of PRP was achieved by RegenLab THT tube? method. Subsequently, patients were randomly divided into two groups: group A, which also underwent a fractional CO₂ laser resurfacing at 15 W; and group B, which only underwent nanofat and PRP infiltration. The original questionnaire of quality of life questionnaire (QoL-Q) was also administered pre- and postoperatively to analyse satisfaction and aesthetical perception of the result. Results:Preoperative thickness of subcutaneous tissue of patients from group A was 0.532 mm, whilst preoperative thickness of subcutaneous tissue of patients from group B was 0.737 mm. Postoperative thickness of subcutaneous tissue was 1.201 mm in group A and 1.367 mm in group B. The improvement of thickness of subcutaneous tissue was 0.668 mm in group A and 0.630 mm in group B. The authors applied a t-test on unpaired data, comparing the difference in thickness obtained with the treatment both in group A and in group B, with a P = 0.7289 (not significant). All patients in both groups had a treatment benefit. Conclusion:Combined approach with nanofat, PRP and CO₂ laser seems to be effective to improve trophic scars, however, infiltration alone proved to significantly increase skin and subcutaneous tissue thickness. QoL-Q confirmed the impact of acne scars on the face in social life and relationships .

     Keywords:Acne; scars; regenerative; laser; nano-fat .

     原文链接

     各位读者可复制此链接到浏览器中打开。

     http://parjournal.net/article/view/1579

     或可点击屏幕左下方“阅读原文”，免费获取全文!

     本文是“EuRePS Meeting 2015: best five papers”专题里面的一篇，想要了解更多此专题文章，请复制链接

     http://parjournal.net/journal/section/75到浏览器中阅读。

     联系我们

     Plastic and Aesthetic Research旨在传播整形与美容领域最新研究进展，为该领域的研究学者和临床医生提供一个国际性学术交流平台。期刊受众群体来自全球173个国家，已在线发表文章198篇，我们诚挚地欢迎您向我刊投稿，如有需求，请邮件：

     par_editor001@parjournal.net。

     本文摘要由北京协和医学院整形外科医院激光美容中心 黄绿萍教授 翻译提供，中文内容仅供参考，一切以英文原版为主。

     本文转载已获OAE 微信号 授权 更多精彩，点击下方“阅读原文”查看。

    http://weixin.100md.com
返回 创新医学网 返回首页 返回百拇医药