【文献解读】局部肝素外用在烧伤治疗中的作用：南印度卡纳塔克邦地区政府医院的经验
2017/9/26 创新医学网

    

    

     文章来源：欧尔意 OAE 微信号

     作者：Sofina

    

     原文出处

     Gupta A, Verghese TJ, Gupta P, Gupta AK. Role of topical heparin in the management of burns: experience in a district government hospital of Karnataka in South India. Plast Aesthet Res 2015;2:111-4.

     DOI: 10.4103/2347-9264.157100

     摘要

     目的：肝素是一种具有多种作用的化合物，不仅可用作抗凝血剂，还有抗炎，抗过敏，抗组胺，抗血清素，抗蛋白水解和促新血管生成等作用。本文目的是研究局部外用肝素对二度烧伤的治疗效果。方法：将2005年12月至2007年1月间的60例10-60岁，烧伤深度为I度-II度、面积在10-60%TBSA热烧伤患者随机分为对照组(C组)和肝素组(H组)，每组30例。结果：肝素治疗组患者相较对照组疼痛缓解、伤口愈合快、并发症少和缩短了住院时间，两组具有统计学差异。大多数入院患者正是家庭经济支柱的年龄(青壮年)，而且主要是女性。两组的基本资料包括年龄，烧伤类型、程度无统计学差异。结论：本研究表明局部外用肝素具有治疗I度和II度烧伤的作用。

     关键词：获益，烧伤，成本，流行病学，肝素

     Aim: Heparin is a multifaceted compound with uses not only as an anticoagulant, but also as an anti-infammatory, anti-allergenic, anti-histaminic, anti-serotonin, anti-proteolytic and neoangiogenic agent. The aim of the study was to study the effect of topical heparin in the management of second-degree burns. Methods: Between December 2005 and January 2007, 60 consecutive patients, aged 10-60 years, with first-and second-degree thermal injuries ranging from 10% to 60%, were randomly enrolled in the study divided into a control group (C) and a heparin group (H) of 30 patients each. Results: Patients treated with topical heparin experienced statistically significant improved pain relief, faster healing, fewer complications and shorter hospital stays. The majority of the patients admitted were in an economically productive age group and were predominantly female. The distribution between the two groups according to age, type of burns and extent of burns was not statistically different. Conclusion: The current study demonstrates the efficacy of topical heparin in the treatment of first- and second-degree burns.

     Keywords: Benefits, burns, cost, epidemiology, heparin

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