【文献解读】天然抗氧化物在肝癌治疗中的作用
2018/1/2 创新医学网

    

    

     文章来源：欧尔意 OAE 微信号

     作者：Sofina

    

     原文出处

     Hassan HA, El-Gharib NE, Azhari AF. Role of natural antioxidants in the therapeutic management of hepatocellular carcinoma. Hepatoma Res 2016;2:216-23.

     DOI: 10.20517/2394-5079.2016.12

     摘要

     肝细胞癌(HCC)是人类日益增长的健康问题。它被认为是导致人类死亡的最常见的内部恶性肿瘤。但在西方发达国家，HCC发病率较低，主要发生于慢性肝病。HCC与很多危险因素相关，包括乙肝病毒感染，丙肝病毒感染，长期黄曲霉素暴露及酒精性肝硬化。总的来说，三分之一的肝硬化患者在其一生中会发生HCC。 此外，化学致癌物通过自由基代谢产物引起肿瘤促进，引起许多诱导氧化应激的生物化学和分子变化。HCC分期和潜在肝脏状态的鉴定及选择最佳的治疗方案(外科切除，放疗和化疗)将有助于提高患者的生存率和生活质量。考虑到一些天然抗氧化物对提高身体素质的营养价值，本文将对不同天然抗氧化物对HCC治疗的功效及其机制进行总结。。

     关键词：肝细胞癌，危险因子，天然抗氧化物

     Abstract：Hepatocellular carcinoma (HCC) is a growing health problem in humans. HCC is considered the most common of internal malignancy which cause the death of human, but in the developed Western world, HCC is less common accompanied by increasing essentially in incidence, due to it occurs specially in chronic liver disease. HCC associated with various risk factors including hepatitis B virus infection; hepatitis C virus infection; prolonged aflatoxin exposure; and alcoholic cirrhosis. Overall, one-third of cirrhosis patients will develop HCC during their life time. Also, chemical carcinogens cause tumor promotions through free radical metabolites result in many biochemical and molecular changes that induces oxidative stress. The identify of HCC stage and underlying liver status then choosing the most appropriate line of therapy (surgical, loco regional, radiological and medical) can be improve the survival and/or the quality of life of the patient. Taken into the account of the nutritional value of some natural antioxidant agents that support the function of the body resulting an improvement of the health and protection from different diseases, our review will provide an up-dated status of the different aspects of HCC management through covering the efficacy and the beneficial effects of different natural agents and their mechanism of action against HCC for the future therapy modalities.

     Keywords:Hepatocellular carcinoma; risk factors; natural antioxidants

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