抗Ro52阳性而抗Ro60阴性,都是风湿病吗?
2017/9/21 医学界风湿免疫频道

    

     文献阅读时间。

     作者 | Murng SHK et al.

     翻译 | 北医三院 赵金霞(zhao-jinxia@163.com)

     审校 | 柴静

     来源 | 中国风湿病公众论坛

     文献摘要

     目的:传统观点认为抗SSA/Ro是针对Ro52 和Ro60抗原的自身抗体。通常抗SSA/Ro阳性包括Ro52+Ro60+或Ro52-Ro60+。抗Ro52阳性而抗Ro60阴性 (Ro52+ Ro60-)常不被报告。本研究在于分析这些自身抗体在结缔组织病处理中的潜在意义。

     方法:作为NHS格拉斯哥和克莱德(GGC)免疫实验室抗可提取性核抗原抗体评价服务的一部分,对Ro52+Ro60-结果进行回顾性分析。分析97例Ro52+Ro60- 和100例Ro52+Ro60+患者的临床和实验室资料。

     结果:71例(73%) 抗Ro52+Ro60-的患者被诊断为自身免疫性疾病包括未分化结缔组织病(n=14, 14%),系统性红斑狼疮(n=10, 10%),干燥综合征 (n=10, 10%) 和类风湿关节炎(n=13, 13%)。23例(24%) 抗Ro52+Ro60-的患者无自身免疫性疾病的临床表现但是具有明显的临床病症包括恶性肿瘤。与之相比,87例 (87%) 抗Ro52+Ro60+ 患者具有自身免疫性疾病包括干燥综合征(n=34, 34%),系统性红斑狼疮 (SLE; n=23, 23%),未分化结缔组织病(n=12, 12%) 和类风湿关节炎 (n=6, 6%).

     结论:抗Ro52阳性而抗Ro60阴性(Ro52+Ro60-)也应该报告。大部分具有这些自身抗体的患者与各种自身免疫性疾病相关。抗Ro52+Ro60-也可以见于肿瘤等其他疾病,这些患者可以无任何自身免疫病的相关表现。

     附原文

     Abstract AIMS:Autoantibodies targeting Ro52 and Ro60 antigens are historically reported as anti SSA/Ro. In general anti SSA/Ro results are either anti Ro52+Ro60+ or anti Ro52-Ro60+ antibodies. Anti Ro52 without anti Ro60 (Ro52+ Ro60-) antibodies are often not reported routinely. This study intends to review the potential significance of these autoantibodies in the management of connective tissue diseases.

     METHOD:A retrospective survey of Ro52+Ro60- was carried out as part of the service evaluation of extractable nuclear antigen antibodies (ENA) reporting from the immunology laboratory, the NHS Greater Glasgow and Clyde (GGC), UK. The clinical documents and laboratory results of 97 patients with Ro52+Ro60- and 100 patients with Ro52+Ro60+ were reviewed.

     RESULTS:Seventy-one patients (73%) with anti Ro52+Ro60- antibodies have been diagnosed with autoimmune conditions including undifferentiated connective tissue diseases (n=14, 14%), systemic lupus erythematosus (n=10, 10%), Sj?gren's syndrome (n=10, 10%) and rheumatoid arthritis (n=13, 13%). Twenty-three patients (24%) with anti Ro52+Ro60- antibodies have no autoimmune features but were found to have significant clinical conditions including malignancies. In contrast, 87 patients (87%) with anti Ro52+Ro60+ antibodies have autoimmune conditions including Sj?gren's syndrome (n=34, 34%), systemic lupus erythematosus (SLE; n=23, 23%), undifferentiated connective tissue diseases (n=12, 12%) and rheumatoid arthritis (n=6, 6%).

     CONCLUSION:Anti Ro52 without anti Ro60 (Ro52+Ro60-) antibodies should be reported. In the majority of patients these autoantibodies were associated with various autoimmune diseases. Anti Ro52+Ro60- antibodies were also found in patients with significant clinical conditions including malignancies even though there was no suggestion of autoimmunity at the time of testing.

     引自

     Murng SHK,Thomas M.Clinical associations of the positive anti Ro52 without Ro60 autoantibodies: undifferentiated connective tissue diseases. J Clin Pathol. 2017 Jun 29. pii: jclinpath-2015-203587. doi: 10.1136/jclinpath-2015-203587. [Epub ahead of print]

    

    


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